Peptide Signals Encode Protein Localization
نویسندگان
چکیده
منابع مشابه
Peptide signals encode protein localization.
Many bacterial proteins are localized to precise intracellular locations, but in most cases the mechanism for encoding localization information is not known. Screening libraries of peptides fused to green fluorescent protein identified sequences that directed the protein to helical structures or to midcell. These peptides indicate that protein localization can be encoded in 20-amino-acid peptid...
متن کاملLocSigDB: a database of protein localization signals
LocSigDB (http://genome.unmc.edu/LocSigDB/) is a manually curated database of experimental protein localization signals for eight distinct subcellular locations; primarily in a eukaryotic cell with brief coverage of bacterial proteins. Proteins must be localized at their appropriate subcellular compartment to perform their desired function. Mislocalization of proteins to unintended locations is...
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Peptide and protein drugs have found an important position in therapeutics. Recent advances in pharmaceutical biotechnology have led to an increase in the number of protein products in the market. As these therapeutic proteins and peptides are made available, it will be essential to formulate these drugs into safe and effective delivery systems. The twenty different naturally occurring amin...
متن کاملPeptide and Protein Delivery at a Glance
Peptide and protein drugs have found an important position in therapeutics. Recent advances in pharmaceutical biotechnology have led to an increase in the number of protein products in the market. As these therapeutic proteins and peptides are made available, it will be essential to formulate these drugs into safe and effective delivery systems. The twenty different naturally occurring amin...
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Red blood cell protein 4.1, 4.1R, represents an extreme variation on the theme of isoform multiplicity. The diverse 4.1R isoforms, generated by alternative pre-mRNA splicing, are localized at different intracellular sites. We cloned human lymphoid 4.1R cDNAs to define specific domains involved in differential intracellular targeting of 4.1R. Thirteen 4.1R isoforms were identified, four of them ...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 2007
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.00981-07